Jadhav, VaishnaviLuo, QianyiM. Dominguez, JamesAl-Sabah, JudeChaqour, BrahimGrant, Maria B.Bhatwadekar, Ashay D.2016-12-212016-12-212016Jadhav, V., Luo, Q., 2nd, J. M. D., Al-Sabah, J., Chaqour, B., Grant, M. B., & Bhatwadekar, A. D. (2016). Per2-Mediated Vascular Dysfunction Is Caused by the Upregulation of the Connective Tissue Growth Factor (CTGF). PLOS ONE, 11(9), e0163367. https://doi.org/10.1371/journal.pone.01633671932-6203https://hdl.handle.net/1805/11684Period 2-mutant mice (Per2m/m), which possess a circadian dysfunction, recapitulate the retinal vascular phenotype similar to diabetic retinopathy (DR). The vascular dysfunction in Per2m/m is associated with an increase in connective tissue growth factor (CTGF/CCN2). At the molecular level, CTGF gene expression is dependent on the canonical Wnt/β-catenin pathway. The nuclear binding of β-catenin to a transcription factor, lymphoid enhancer binding protein (Lef)/en-USAttribution 4.0 InternationalDiabetesRetinal vesselsProtein expressionArticle