Markel, TroyJensen, Amanda2018-08-092018-08-092017https://hdl.handle.net/1805/17057http://dx.doi.org/10.7912/C2/2774Indiana University Purdue University IndianapolisH2S is a gaseous mediator that acts as an anti-inflammatory agent contributing to gastrointestinal mucosal defense. It promotes vascular dilation, mucosal repair, and resolution of inflammation following intestinal ischemia and may be exploited as a novel therapeutic agent. It is unclear if H2S works through nitric oxide-dependent pathways in the intestine. We appreciated that H2S was able to improve post-ischemic recovery of mesenteric perfusion, mucosal integrity, and inflammation. The beneficial effects of H2S appear to be mediated through endothelial nitric oxide-dependent pathways.en-USAttribution-NonCommercial-NoDerivs 3.0 United StatesH2SeNOSIntestinal ischemia10.7912/C2PH2K