Butler, Merlin G.Meaney, F. JohnKaler, Stephen G.2018-03-052018-03-051986-06BUTLER, M. G., MEANEY, F. J., & KALER, S. G. (1986). Metacarpophalangeal Pattern Profile Analysis in Clinical Genetics: An Applied Anthropometric Method. American Journal of Physical Anthropology, 70(2), 195–201. https://doi.org/10.1002/ajpa.13307002060002-9483https://hdl.handle.net/1805/15357The hand is a complex anatomical structure with the component bones susceptible to a combination of environmental and genetic factors that may affect the bone length and width. The alterations may involve a single bone or specific group of bones. The metacarpophalangeal pattern profile (MCPP) developed by Poznanski, Garn, and others (Poznanski et al. Birth Defects VIII (5): 125–131, 1972) is a graphic representation of the relative lengthening and shortening of the 19 tubular bones of the hand useful for diagnosis, comparison of dissimilar patients, and gene carrier detection. The profile hand bone measurements are derived from posteroanterior hand radiographs and are standardized for age and sex. Specific profiles have been developed for several syndromes. Therefore, MCPP analysis has developed from a method of describing changes in the hand to a technique useful in assigning a diagnosis to a specific syndrome and evaluation of skeletal development. The current status of MCPP analysis in clinical genetics, particularly with the Prader-Labhart-Willi and Sotos syndromes, is discussed.en-USPublisher PolicyPrader-Labhart-Willi syndromeSotos syndromeDiscriminant analysisCorrelation studiesArticle