Aruldhas, Blessed W.Quinney, Sara K.Packiasabapathy, SenthilOverholser, Brian R.Raymond, OliviaSivam, SahanaSivam, IneshVelu, SanjanaMontelibano, AntoinetteSadhasivam, Senthilkumar2024-06-252024-06-252023Aruldhas BW, Quinney SK, Packiasabapathy S, et al. Effects of oxycodone pharmacogenetics on postoperative analgesia and related clinical outcomes in children: a pilot prospective study. Pharmacogenomics. 2023;24(4):187-197. doi:10.2217/pgs-2022-0149https://hdl.handle.net/1805/41877Background: Variability in the pharmacokinetics and pharmacodynamics of oxycodone in children undergoing surgery could be due to genetic polymorphisms. Materials & methods: The authors studied the association between clinical outcomes and pharmacogenes in children undergoing major surgery. A total of 89 children (35 undergoing pectus excavatum repair and 54 undergoing spinal fusion) were recruited. Results: OPRM1 SNP rs6902403 showed an association with maximum pain score and total morphine equivalent dose (p < 0.05). Other polymorphisms in OPRM1 SNP, PXR, COMT and ABCB1 were also shown to be associated with average morphine equivalent dose, length of hospital stay and maximum surgical pain (p < 0.05). Conclusion: This study demonstrates novel associations between the above pharmacogenes and oxycodone's pharmacokinetics as well as postoperative outcomes in children.en-USPublisher PolicyABCB1AnalgesiaChildrenHospital stayOxycodonePharmacogeneticsPharmacokineticsArticle