Ventresca, ChristaMartschenko, Daphne O.Wedow, RobbeeCivelek, MeteTabery, JamesCarlson, JedidiahParker, Stephen C. J.Ramos, Paula S.2025-05-132025-05-132024Ventresca C, Martschenko DO, Wedow R, et al. The methodological and ethical concerns of genetic studies of same-sex sexual behavior. Am J Hum Genet. 2024;111(10):2107-2116. doi:10.1016/j.ajhg.2024.08.007https://hdl.handle.net/1805/48044Same-sex sexual behavior has long interested genetics researchers in part because, while there is evidence of heritability, the trait as typically defined is associated with fewer offspring. Investigations of this phenomenon began in the 1990s with linkage studies and continue today with the advent of genome-wide association studies. As this body of research grows, so does critical scientific and ethical review of it. Here, we provide a targeted overview of existing genetics studies on same-sex sexual behavior, highlight the ethical and scientific considerations of this nascent field, and provide recommendations developed by the authors to enhance social and ethical responsibility.en-USPublisher PolicyGenome-wide association studyHomosexualitySexual behaviorArticle