Jiang, YanlinZhou, ShaoyuSandusky, George E.Kelley, Mark R.Fishel, Melissa L.2014-07-302014-07-302010-11Jiang, Y., Zhou, S., Sandusky, G. E., Kelley, M. R., & Fishel, M. L. (2010). Reduced expression of DNA repair and redox signaling protein APE1/Ref-1 impairs human pancreatic cancer cell survival, proliferation, and cell cycle progression. Cancer investigation, 28(9), 885-895.https://hdl.handle.net/1805/4816Pancreatic cancer is a deadly disease that is virtually never cured. Understanding the chemoresistance intrinsic to this cancer will aid in developing new regimens. High expression of APE1/Ref-1, a DNA repair and redox signaling protein, is associated with resistance, poor outcome, and angiogenesis; little is known in pancreatic cancer. Immunostaining of adenocarcinoma shows greater APE1/Ref-1 expression than in normal pancreas tissue. A decrease in APE1/Ref-1 protein levels results in pancreatic cancer cell growth inhibition, increased apoptosis, and altered cell cycle progression. Endogenous cell cycle inhibitors increase when APE1/ Ref-1 is reduced, demonstrating its importance to proliferation and growth of pancreatic cancer.en-USpancreatic cancerAPE1/Ref-1cell cycleArticle