Menakuru, Sasmith R.Dhillon, Vijaypal S.Salih, AhmedBeirat, Amir F.2024-01-102024-01-102023-05-15Menakuru SR, Dhillon VS, Salih A, Beirat AF. Acquired Factor X Deficiency without Amyloidosis Presenting with Massive Hematuria: A Case Report and Review of the Literature. Hematol Rep. 2023;15(2):312-316. Published 2023 May 15. doi:10.3390/hematolrep15020032https://hdl.handle.net/1805/37927Acquired factor X deficiency is a rare diagnosis, especially without the association of other co-existing conditions such as amyloidosis. The authors report the case of a 34-year-old male with severe frank hematuria found to have markedly prolonged prothrombin time and activated partial thromboplastin time. A mixing study showed correction utilizing normal plasma and a coagulation panel testing revealed decreased factor X activity. The patient was treated with multiple blood transfusions, fresh frozen plasma, high-dose pulse steroids, and rituximab. The patient’s condition improved during his 21-day hospital stay and was followed up every 2 weeks for 3 months. The patient’s factor X level recovered after two weeks of discharge with no other hemorrhagic episodes.en-USAttribution 4.0 InternationalAcquired factor X deficiencyCOVID-19HematuriaWithout amyloidosisArticle