Xie, JingwuZhang, Xiaoli2016-10-072016-10-072016-01Xie, J., & Zhang, X. (2016). The Impact of Genomic Profiling for Novel Cancer Therapy–Recent Progress in Non-Small Cell Lung Cancer. Journal of Genetics and Genomics, 43(1), 3-10. http://dx.doi.org/10.1016/j.jgg.2015.09.003https://hdl.handle.net/1805/11152There is high expectation for significant improvements in cancer patient care after completion of the human genome project in 2003. Through pains-taking analyses of genomic profiles in cancer patients, a number of targetable gene alterations have been discovered, with some leading to novel therapies, such as activating mutations of EGFR, BRAF and ALK gene fusions. As a result, clinical management of cancer through targeted therapy has finally become a reality for a subset of cancers, such as lung adenocarcinomas and melanomas. In this review, we summarize how gene mutation discovery leads to new treatment strategies using non-small cell lung cancer (NSCLC) as an example. We also discuss possible future implications of cancer genome analyses.enIUPUI Open Access Policytargeted therapylung cancergene mutationArticle