Comer, Amber R.Williams, Linda S.Bartlett, StephanieD'Cruz, LynnEndris, KatlynMarchand, McKenzieZepeda, IsabelToor, SumeetWaite, CarlyJawed, AreebaHolloway, RobertCreutzfeldt, Claire J.Slaven, James E.Torke, Alexia M.2023-08-302023-08-302022-05Comer, A. R., Williams, L. S., Bartlett, S., D’Cruz, L., Endris, K., Marchand, M., Zepeda, I., Toor, S., Waite, C., Jawed, A., Holloway, R., Creutzfeldt, C. J., Slaven, J. E., & Torke, A. M. (2022). Palliative and End-of-Life Care After Severe Stroke. Journal of Pain and Symptom Management, 63(5), 721–728. https://doi.org/10.1016/j.jpainsymman.2021.12.03234995684https://hdl.handle.net/1805/35255Background and Objectives The distinct illness trajectory after acute ischemic stroke demands a better understanding of the utilization of palliative care consultations (PCC) for this patient cohort. This study sought to determine the prevalence, predictors, and outcomes associated with PCC for patients hospitalized with severe ischemic stroke. Methods This multicenter cohort study was conducted at four hospitals (2 comprehensive and 2 primary stroke centers) between January, 2016 and December, 2019. We included all patients with a discharge diagnosis of ischemic stroke and an initial National Institutes of Health Stroke Scale (NIHSS) of 10 or greater. We compared patient sociodemographic, clinical and care characteristics as well as hospital outcomes between patients who did and did not receive PCC. Results The study included 1297 patients hospitalized with severe ischemic stroke. PCC occurred for 20% of all patients and this proportion varied across institutions from 11.9% to 43%. Less than half (43%) of patients who died in the hospital. In multivaraible analysis, PCC was less likely in female patients (OR .76, 95% CI .59, .99, P=0.04) but more likely in patients with higher NIHSS (OR1.95, 95% CI 1,13, 3.37, P=0.02). Patients with PCC had higher rates of moving to a plan focused on comfort measures (CMO) (P<0.01) and removal of artificial nutrition as part of a move to CMO (P<0.01). In a sub analysis of patients who died in the hospital and received PCC, patients who died on or before hospital day 3 were less likely to receive PCC than patients who died on or after hospital day 4 (24% v. 51%) (P=<0.01). Conclusions Most patients with severe stroke do not receive PCC, even among those who experience in-hospital death. The results of this study indicate there are missed opportunities for PCC to help reduce suffering after severe stroke.enAttribution-NonCommercial-NoDerivatives 4.0 InternationalPalliative Careend-of-lifestrokeArticle