Broxmeyer, Hal E.Cooper, ScottBlum, Janice S.2023-08-282023-08-282021Broxmeyer HE, Cooper S, Blum JS. Expression of gilt acts as a positive regulator of mouse hematopoietic progenitor cells. Blood Cells Mol Dis. 2021;90:102574. doi:10.1016/j.bcmd.2021.102574https://hdl.handle.net/1805/35176Gamma interferon inducible lysosomal thiol reductase (GILT), is known to be involved in immunity, but its role in hematopoiesis has not been previously reported. Herein, we demonstrate using gilt knockout (-/-) mice that loss of gilt associates with decreased numbers and cycling status of femoral hematopoietic progenitor cells (CFU-GM, BFU-E, and CFU-GEMM) with more modest effects on splenic progenitor cells. Thus, GILT is associated with positive regulation of hematopoietic progenitor cells in mice, mainly in bone marrow.en-USPublisher PolicyGiltBone marrowSpleenHematopoietic progenitor cellsArticle