Fowler, Nicole R.Perkins, Anthony J.Park, SehoSchroeder, Matthew W.Boustani, Malaz A.Head, Katharine J.Bakas, Tamilyn2025-04-222025-04-222024Fowler, N. R., Perkins, A. J., Park, S., Schroeder, M. W., Boustani, M. A., Head, K. J., & Bakas, T. (2024). Relationship between health-related quality of life, depression, and anxiety in older primary care patients and their family members. Aging & Mental Health, 28(6), 910–916. https://doi.org/10.1080/13607863.2023.2285499https://hdl.handle.net/1805/47296Objectives Patient-family member dyads experience transitions through illness as an interdependent team. This study measures the association of depression, anxiety, and health-related quality of life (HRQOL) of older adult primary care patient-family member dyads. Methods Baseline data from 1,808 patient-family member dyads enrolled in a trial testing early detection of Alzheimer’s disease and related dementias in primary care. Actor-Partner Independence Model was used to analyze dyadic relationships between patients’ and family members’ depression (PHQ-9), anxiety (GAD-7), and HRQOL (SF-36 Physical Component Summary score and Mental Component Summary score). Results Family member mean (SD) age is 64.2 (13) years; 32.2% male; 84.6% White; and 64.8% being the patient’s spouse/partner. Patient mean (SD) age is 73.7 (5.7) years; 47% male; and 85.1% White. For HRQOL, there were significant actor effects for patient and family member depression alone and depression and anxiety together on their own HRQOL (p < 0.001). There were significant partner effects where family member depression combined with anxiety was associated with the patient’s physical component summary score of the SF-36 (p = 0.010), and where the family member’s anxiety alone was associated with the patient’s mental component summary score of the SF-36 (p = 0.031). Conclusion Results from this study reveal that many dyads experience covarying health status (e.g. depression, anxiety) even prior to entering a caregiving situation.enAttribution-NonCommercial-NoDerivatives 4.0 Internationalquality of lifemental healtholder adultsArticle