Irving, Charles D.Floreancig, Jack T.Gasonoo, MakafuiKelley, Alexandra S.Laulhé, Sébastien2024-01-042024-01-042021Irving CD, Floreancig JT, Gasonoo M, Kelley AS, Laulhé S. Synthesis of Imide and Amine Derivatives via Deoxyamination of Alcohols Using N-Haloimides and Triphenylphosphine. ChemistrySelect. 2021;6(33):8874-8878. doi:10.1002/slct.202102296https://hdl.handle.net/1805/37603A deoxyamination methodology of activated and unactivated alcohols is presented. The reaction is mediated by phosphonium intermediates generated in situ from N-haloimides and triphenylphosphine. The protocol allows for the synthesis of phthalimide and amine derivatives in moderate to good yields at room temperature. A series of NMR experiments have provided insight into the reactive intermediates involved and the mechanism of this deoxyamination reaction.en-USPublisher PolicyAmine precursorsDeoxyaminationMitsunobu reactionN-haloimidesTriphenylphosphineArticle