Bose, SubhasishPathireddy, SamataBaradhi, Krishna M.Aeddula, Narothama Reddy2019-07-302019-07-302019-01-29Bose, S., Pathireddy, S., Baradhi, K. M., & Aeddula, N. R. (2019). Alport's syndrome and intracranial aneurysm: mere coincidence or undiscovered causal relationship. BMJ case reports, 12(1), e228175. doi:10.1136/bcr-2018-228175https://hdl.handle.net/1805/20040A 44-year-old Caucasian man with a history of deceased donor renal transplant for end-stage renal disease from Alport's syndrome (AS), presented with a spontaneous subarachnoid haemorrhage and hydrocephalus. Following an external ventricular drain for the hydrocephalus, a CT angiography revealed a dissection of the left vertebral artery extending into vertebro-basilar junction necessitating a bypass between left occipital artery to left posterior inferior cerebellar artery. He had a posterior fossa Craniectomy, C1 laminectomy and coiling off, of the left vertebral artery. Postprocedure course was prolonged but uneventful with complete recovery and normal renal function 18 months postpresentation. AS, a disease caused by abnormalities in the synthesis of type IV collagen, can cause aneurysms with severe and permanent neurological sequalae. We present a case of AS with intracranial arterial dissection with potential life-threatening consequences and discuss the genetic and molecular basis of AS along with review of the relevant literature.en-USAttribution-NonCommercial-NoDerivs 3.0 United StatesNeuroimagingNeuro ituInterventional radiologyRenal transplantationStrokeArticle