Resnick, BarbaraZimmerman, SherylGaugler, JosephOuslander, JosephAbrahamson, KathleenBrandt, NicoleColón-Emeric, CathleenGalik, ElizabethGravenstein, StefanMody, LonaSloane, Philip D.Unroe, KathleenVerbeek, Hilde2023-11-162023-11-162022-08Resnick B, Zimmerman S, Gaugler J, et al. Pragmatic Trials in Long-Term Care: Research Challenges and Potential Solutions in Relation to Key Areas of Care [published correction appears in J Am Med Dir Assoc. 2022 Aug;23(8):1435]. J Am Med Dir Assoc. 2022;23(3):330-338. doi:10.1016/j.jamda.2021.12.011https://hdl.handle.net/1805/37095As a method of research, pragmatic trials are recommended so as to generate results that are applicable to real-world care. This intent is especially important for the millions of older adults who receive long-term care in thousands of nursing homes and assisted living communities across the country-and many millions more around the globe. This article presents key points raised by experts participating in a conference funded by the National Institute of Aging held at the 2021 conference of the Society for Post-Acute and Long-term Care Medicine. The purpose of the conference was to convene leading clinicians, researchers, and industry partners to address special considerations of pragmatic trials in long-term care. Cross-cutting and unique challenges and solutions to conducting pragmatic trials were discussed focusing on 3 areas of clinical relevance to long-term care: (1) functional care and outcomes, (2) psychosocial care and quality of life, and (3) medical care and outcomes, with a special focus on persons with dementia. Challenges and innovative solutions were organized across the 9 domains of the revised Pragmatic-Explanatory Continuum Indicator Summary (PRECIS) Tool, and future research recommendations for pragmatic trials in long-term care were identified.en-USPublisher PolicyLong-term careNursing homesQuality of lifeAgedArticle