Recent Advances in Synthetic Methods by Photocatalytic Single-Electron Transfer Chemistry of Pyridine N-Oxides

Satheesh, VanaparthiDeng, Yongming2024-10-282024-10-282024Satheesh V, Deng Y. Recent Advances in Synthetic Methods by Photocatalytic Single-Electron Transfer Chemistry of Pyridine N-Oxides. J Org Chem. 2024;89(17):11864-11874. doi:10.1021/acs.joc.4c01453https://hdl.handle.net/1805/44249By adoption of the enabling technology of modern photoredox catalysis and photochemistry, the generation of reactive and versatile pyridine N-oxy radicals can be facilely achieved from single-electron oxidation of pyridine N-oxides. This Synopsis highlights recent methodologies mediated by pyridine N-oxy radicals in developing (1) pyridine N-oxide-based hydrogen atom transfer catalysts for C(sp3)-H functionalizations and (2) β-oxyvinyl radical-mediated cascade reactions. In addition, recent research revealed that direct photoexcitation of pyridine N-oxides allowed for the generation of alkyl carbon radicals from alkylboronic acids.en-USPublisher PolicyPhotoredox catalysisPhotochemistryN-oxy radicalsRecent Advances in Synthetic Methods by Photocatalytic Single-Electron Transfer Chemistry of Pyridine N-OxidesArticle