Peterson, AmaliaSathe, AditiZaras, DimitriosYang, YisuDurant, AlainaDeters, Kacie D.Shashikumar, NiranjanaPechman, Kimberly R.Kim, Michael E.Gao, ChenyuKhairi, Nazirah MohdLi, ZhiyuanYao, TianyuanHuo, YuankaiDumitrescu, LoganGifford, Katherine A.Wilson, Jo EllenCambronero, FrancisRisacher, Shannon L.Beason-Held, Lori L.An, YangArfanakis, KonstantinosErus, GurayDavatzikos, ChristosTosun, DuyguToga, Arthur W.Thompson, Paul M.Mormino, Elizabeth C.Zhang, PanpanSchilling, KurtAlzheimer’s Disease Neuroimaging Initiative (ADNI)BIOCARD Study Team; Alzheimer’s Disease Sequencing Project (ADSP)Albert, MarilynKukull, WalterBiber, Sarah A.Landman, Bennett A.Johnson, Sterling C.Schneider, JulieBarnes, Lisa L.Bennett, David A.Jefferson, Angela L.Resnick, Susan M.Saykin, Andrew J.Hohman, Timothy J.Archer, Derek B.2024-08-302024-08-302024-06-12Peterson A, Sathe A, Zaras D, et al. Sex, racial, and APOE-ε4 allele differences in longitudinal white matter microstructure in multiple cohorts of aging and Alzheimer's disease. Preprint. bioRxiv. 2024;2024.06.10.598357. Published 2024 Jun 12. doi:10.1101/2024.06.10.598357https://hdl.handle.net/1805/43056Introduction: The effects of sex, race, and Apolipoprotein E (APOE) - Alzheimer's disease (AD) risk factors - on white matter integrity are not well characterized. Methods: Diffusion MRI data from nine well-established longitudinal cohorts of aging were free-water (FW)-corrected and harmonized. This dataset included 4,702 participants (age=73.06 ± 9.75) with 9,671 imaging sessions over time. FW and FW-corrected fractional anisotropy (FAFWcorr) were used to assess differences in white matter microstructure by sex, race, and APOE-ε4 carrier status. Results: Sex differences in FAFWcorr in association and projection tracts, racial differences in FAFWcorr in projection tracts, and APOE-ε4 differences in FW limbic and occipital transcallosal tracts were most pronounced. Discussion: There are prominent differences in white matter microstructure by sex, race, and APOE-ε4 carrier status. This work adds to our understanding of disparities in AD. Additional work to understand the etiology of these differences is warranted.en-USAttribution-NonCommercial-NoDerivatives 4.0 InternationalSexRaceApolipoprotein E (APOE)Alzheimer's disease (AD)Article