Machogu, EvansGaston, Benjamin2022-06-142022-06-142021-02-18Machogu E, Gaston B. Respiratory Distress in the Newborn with Primary Ciliary Dyskinesia. Children (Basel). 2021;8(2):153. Published 2021 Feb 18. doi:10.3390/children8020153https://hdl.handle.net/1805/29343Primary ciliary dyskinesia (PCD) is inherited in a predominantly autosomal recessive manner with over 45 currently identified causative genes. It is a clinically heterogeneous disorder that results in a chronic wet cough and drainage from the paranasal sinuses, chronic otitis media with hearing impairment as well as male infertility. Approximately 50% of patients have situs inversus totalis. Prior to the development of chronic oto-sino-pulmonary symptoms, neonatal respiratory distress occurs in more than 80% of patients as a result of impaired mucociliary clearance and mucus impaction causing atelectasis and lobar collapse. Diagnosis is often delayed due to overlapping symptoms with other causes of neonatal respiratory distress. A work up for PCD should be initiated in the newborn with compatible clinical features, especially those with respiratory distress, consistent radiographic findings or persistent oxygen requirement and/or organ laterality defects.en-USAttribution 4.0 InternationalPrimary ciliary dyskinesiaNeonatal respiratory distressArticle