LeBlanc, Erin S.Desai, ManishaPerrin, NancyWactawski-Wende, JeanManson, JoAnn E.Cauley, Jane A.Michael, Yvonne L.Tang, JeanWomack, CatherineSong, YiqingJohnson, Karen C.O’Sullivan, Mary J.Woods, NancyStefanick, Marcia L.2016-03-302016-03-302014-11LeBlanc, E. S., Desai, M., Perrin, N., Wactawski-Wende, J., Manson, J. E., Cauley, J. A., … Stefanick, M. L. (2014). Vitamin D levels and menopause-related symptoms: Menopause, 21(11), 1197–1203. http://doi.org/10.1097/GME.00000000000002381072-3714 1530-0374https://hdl.handle.net/1805/9100Objective: To determine whether vitamin D levels are associated with menopause-related symptoms in older women. Methods: A randomly selected subset of 1,407 women, among 26,104 potentially eligible participants of the Women’s Health Initiative Calcium and Vitamin D (CaD) trial of postmenopausal women aged 51-80 years, had 25-hydroxyvitamin D [25(OH)D] levels measured at the CaD trial baseline visit. Information about menopause-related symptoms at baseline was obtained by questionnaire and included overall number of symptoms and composite measures of sleep disturbance, emotional well-being, and energy/fatigue, as well as individual symptoms. After exclusions for missing data, 530 women [mean age 66.2 years (SD 6.8)] were included in these analyses. Results: There were borderline significant associations between 25(OH)D levels and total number of menopausal symptoms (p values ranging from 0.05 to 0.06 for fully adjusted models); however, the effect was clinically insignificant and disappeared with correction for multiple testing. There were no associations between 25(OH)D levels and composite measures of sleep disturbance, emotional well-being, or energy/fatigue (p’s > 0.10 for fully adjusted models). Conclusions: There was no evidence of a clinically important association between serum 25(OH)D levels and menopause-related symptoms in postmenopausal women.en-USPublisher's policyVitamin Dmenopausehot flashesmoodsleepArticle