Hibar, Derrek P.Adams, Hieab H.H.Jahanshad, NedaChauhan, GaneshStein, Jason L.Hofer, EdithRenteria, Miguel E.Bis, Joshua C.Arias-Vasquez, AlejandroIkram, M. KamranDesrivières, SylvaneVernooij, Meike W.Abramovic, LucijaAlhusaini, SaudAmin, NajafAndersson, MicaelArfanakis, KonstantinosAribisala, Benjamin S.Armstrong, Nicola J.Athanasiu, LaviniaAxelsson, TomasBeecham, Ashley H.Beiser, AlexaBernard, ManonBlanton, Susan H.Bohlken, Marc M.Boks, Marco P.Bralten, JanitaBrickman, Adam M.Carmichael, OwenChakravarty, MallarChen, QiangChing, Christopher R.K.Chouraki, VincentCuellar-Partida, GabrielCrivello, FabriceDen Braber, AnoukDoan, Nhat TrungEhrlich, StefanGiddaluru, SudheerGoldman, Aaron L.Gottesman, Rebecca F.Grimm, OliverGriswold, Michael E.Guadalupe, TulioGutman, Boris A.Hass, JohannaHaukvik, Unn K.Hoehn, DavidHolmes, Avram J.Hoogman, MartineJanowitz, DeborahJia, TianyeJørgensen, Kjetil N.Karbalai, NazaninKasperaviciute, DaliaKim, SungeunKlein, MariekeKraemer, BerndLee, Phil H.Liewald, David C.M.Lopez, Lorna M.Luciano, MichelleMacare, ChristineMarquand, Andre F.Matarin, MarMather, Karen A.Mattheisen, ManuelMcKay, David R.Milaneschi, YuriManiega, Susana MuñozNho, KwangsikNugent, Allison C.Nyquist, PaulLoohuis, Loes M.Oosterlaan, JaapPapmeyer, MartinaPirpamer, LukasPütz, BennoRamasamy, AdaikalavanRichards, Jennifer S.Risacher, Shannon L.Roiz-Santiañez, RobertoRommelse, NandaRopele, StefanRose, Emma J.Royle, Natalie A.Rundek, TatjanaSämann, Philipp G.Saremi, ArvinSatizabal, Claudia L.Schmaal, LianneSchork, Andrew J.Shen, LiShin, JeanShumskaya, ElenaSmith, Albert V.Sprooten, EmmaStrike, Lachlan T.Teumer, AlexanderTordesillas-Gutierrez, DianaToro, RobertoTrabzuni, DaniahTrompet, StellaVaidya, DhananjayVan der Grond, JeroenVan der Lee, Sven J.Van der Meer, DennisVan Donkelaar, Marjolein M. J.Van Eijk, Kristel R.Van Erp, Theo G.M.Van Rooij, DaanWalton, EstherWestlye, Lars T.Whelan, Christopher D.Windham, Beverly G.Winkler, Anderson M.Wittfeld, KatharinaWoldehawariat, GirmaWolf, ChristianeWolfers, ThomasYanek, Lisa R.Yang, JingyunZijdenbos, AlexZwiers, Marcel P.Agartz, IngridAlmasy, LauraAmes, DavidAmouyel, PhilippeAndreassen, Ole A.Arepalli, SampathAssareh, Amelia A.Barral, SandraBastin, Mark E.Becker, Diane M.Becker, James T.Bennett, David A.Blangero, Johnvan Bokhoven, HansBoomsma, Dorret I.Brodaty, HenryBrouwer, Rachel M.Brunner, Han G.Buckner, Randy L.Buitelaar, Jan K.Bulayeva, Kazima B.Cahn, WiepkeCalhoun, Vince D.Cannon, Dara M.Cavalleri, Gianpiero LCheng, Ching-YuCichon, SvenCookson, Mark R.Corvin, AidenCrespo-Facorro, BenedictoCurran, Joanne E.Czisch, MichaelDale, Anders M.Davies, Gareth E.De Craen, Anton J.M.De Geus, Eco J.C.De Jager, Philip L.De Zubicaray, Greig I.Deary, Ian J.Debette, StéphanieDeCarli, CharlesDelanty, NormanDepondt, ChantalDeStefano, AnitaDillman, AllissaDjurovic, SrdjanDonohoe, GaryDrevets, Wayne C.Duggirala, RaviDyer, Thomas D.Enzinger, ChristianErk, SusanneEspeseth, ThomasFedko, Iryna O.Fernández, GuillénFerrucci, LuigiFisher, Simon E.Fleischman, Debra A.Ford, IanFornage, MyriamForoud, Tatiana M.Fox, Peter T.Francks, ClydeFukunaga, MasakiGibbs, J. RaphaelGlahn, David C.Gollub, Randy L.Göring, Harald H.H.Green, Robert C.Gruber, OliverGudnason, VilmundurGuelfi, SebastianHåberg, Asta K.Hansell, Narelle K.Hardy, JohnHartman, Catharina A.Hashimoto, RyotaHegenscheid, KatrinHeinz, AndreasLe Hellard, StephanieHernandez, Dena G.Heslenfeld, Dirk J.Ho, Beng-CoonHoekstra, Pieter J.Hoffman, WolfgangHofman, AlbertHolsboer, FlorianHomuth, GeorgHosten, NorbertHottenga, Jouke-JanHuentelman, MatthewPol, Hilleke E. HulshoffIkeda, MasashiJack Jr., Clifford R.Jenkinson, MarkJohnson, RobertJönsson, Erik G.Jukema, J. WouterKahn, René SVardarajan, Badri N.Vellas, BrunoVeltman, Dick J.Völzke, HenryWalter, HenrikWardlaw, Joanna M.Wassink, Thomas H.Weale, Michael E.Weinberger, Daniel R.Weiner, Michael W.Kanai, RyotaKloszewska, IwonaKnopman, David S.Kochunov, PeterKwok, John B.Lawrie, Stephen M.Lemaître, HervéLiu, XinminLongo, Dan L.Lopez, Oscar L.Lovestone, SimonMartinez, OliverMartinot, Jean-LucMattay, Venkata S.McDonald, ColmMcIntosh, Andrew M.McMahon, Francis J.McMahon, Katie L.Mecocci, PatriziaMelle, IngridMeyer-Lindenberg, AndreasMohnke, SebastianMontgomery, Grant W.Morris, Derek W.Mosley, Thomas H.Mühleisen, Thomas W.Müller-Myhsok, BertramNalls, Michael A.Nauck, MatthiasNichols, Thomas E.Niessen, Wiro J.Nöthen, Markus M.Nyberg, LarsPurohit, KazutakaOlvera, Rene L.Ophoff, Roel A.Pandolfo, MassimoPaus, TomasPausova, ZdenkaPenninx, Brenda W. J. H.Pike, G. BrucePotkin, Steven G.Psaty, Bruce M.Reppermund, SimoneRietschel, MarcellaRoffman, Joshua L.Romanczuk-Seiferth, NinaRotter, Jerome I.Ryten, MinaSacco, Ralph L.Sachdev, Perminder S.Saykin, Andrew J.Schmidt, ReinholdSchmidt, HelenaSchofield, Peter R.Sigursson, SigurdurSimmons, AndrewSingleton, AndrewSisodiya, Sanjay M.Smith, ColinSmoller, Jordan W.Soininen, HilkkaSteen, Vidar M.Stott, David J.Sussmann, Jessika E.Thalamuthu, AnbupalamToga, Arthur W.Traynor, Bryan J.Troncoso, JuanTsolaki, MagdaTzourio, ChristopheUitterlinden, Andre G.Valdés Hernández, Maria C.Van der Brug, Marcelvan der Lugt, Aadvan der Wee, Nic J. A.Van Haren, Neeltje E. M.van't Ent, DennisVan Tol, Marie-JoseWen, WeiWestman, EricWhite, TonyaWong, Tien Y.Wright, Clinton B.Zielke, Ronald H.Zonderman, Alan B.Martin, Nicholas G.Van Duijn, Cornelia M.Wright, Margaret J.Longstreth, W. T.Schumann, GunterGrabe, Hans J.Franke, BarbaraLauner, Lenore J.Medland, Sarah E.Seshadri, SudhaThompson, Paul M.Arfan, M.2017-06-232017-06-232017-01-18Hibar, D. P., Adams, H. H. H., Jahanshad, N., Chauhan, G., Stein, J. L., Hofer, E., … Ikram, M. A. (2017). Novel genetic loci associated with hippocampal volume. Nature Communications, 8, 13624. http://doi.org/10.1038/ncomms13624https://hdl.handle.net/1805/13160The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (rg=-0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness.en-USAn error occurred on the license name.Hippocampal formationBrainNeuropsychiatric disordersHippocampal abnormalitiesGenesLociHippocampal volume