Dexter, Paul R.Grout, Randall W.Embi, Peter J.2022-08-182022-08-182021-01-25Dexter PR, Grout RW, Embi PJ. Transforming primary medical research knowledge into clinical decision. AMIA Annu Symp Proc. 2021;2020:358-362. Published 2021 Jan 25.https://hdl.handle.net/1805/29829While the utility of computerized clinical decision support (CCDS) for multiple select clinical domains has been clearly demonstrated, much less is known about the full breadth of domains to which CCDS approaches could be productively applied. To explore the applicability of CCDS to general medical knowledge, we sampled a total of 500 primary research articles from 4 high-impact medical journals. Employing rule-based templates, we created high-level CCDS rules for 72% (361/500) of primary medical research articles. We subsequently identified data sources needed to implement those rules. Ourfindings suggest that CCDS approaches, perhaps in the form of non-interruptive infobuttons, could be much more broadly applied. In addition, our analytic methods appear to provide a means of prioritizing and quantitating the relative utility of available data sources for purposes of CCDS.en-USAttribution 4.0 InternationalBiomedical researchClinical decision support systemsBiomedical translational researchArticle