Weaver, Anne M.Khatun-e-Jannat, KanizCercone, EmilyKrytus, KimberlySohel, Badrul MunirAhmed, MakhdumRahman, MustafizurAzziz-Baumgartner, EduardoYu, JihnheeFry, Alicia M.Luby, Stephen P.Ram, Pavani K.2020-05-142020-05-142020Weaver, A. M., Khatun‐e‐Jannat, K., Cercone, E., Krytus, K., Sohel, B. M., Ahmed, M., ... & Luby, S. P. (2017). Household‐level risk factors for secondary influenza‐like illness in a rural area of Bangladesh. Tropical Medicine & International Health, 22(2), 187-195. https://doi.org/10.1111/tmi.12820https://hdl.handle.net/1805/22766This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.Objective To describe household‐level risk factors for secondary influenza‐like illness (ILI), an important public health concern in the low‐income population of Bangladesh. Methods Secondary analysis of control participants in a randomised controlled trial evaluating the effect of handwashing to prevent household ILI transmission. We recruited index‐case patients with ILI – fever (<5 years); fever, cough or sore throat (≥5 years) – from health facilities, collected information on household factors and conducted syndromic surveillance among household contacts for 10 days after resolution of index‐case patients’ symptoms. We evaluated the associations between household factors at baseline and secondary ILI among household contacts using negative binomial regression, accounting for clustering by household. Results Our sample was 1491 household contacts of 184 index‐case patients. Seventy‐one percentage reported that smoking occurred in their home, 27% shared a latrine with one other household and 36% shared a latrine with >1 other household. A total of 114 household contacts (7.6%) had symptoms of ILI during follow‐up. Smoking in the home (RRadj 1.9, 95% CI: 1.2, 3.0) and sharing a latrine with one household (RRadj 2.1, 95% CI: 1.2, 3.6) or >1 household (RRadj 3.1, 95% CI: 1.8–5.2) were independently associated with increased risk of secondary ILI. Conclusion Tobacco use in homes could increase respiratory illness in Bangladesh. The mechanism between use of shared latrines and household ILI transmission is not clear. It is possible that respiratory pathogens could be transmitted through faecal contact or contaminated fomites in shared latrines.enPublisher PolicyThis article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.influenzaBangladeshrespiratory infectionsArticle