Dixon, Brian E.Grannis, Shaun J.Lembcke, LaurenRoberts, AnnaEmbi, Peter J.2021-04-222021-04-222021Dixon, B. E., Grannis, S. J., Lembcke, L., Roberts, A., & Embi, P. J. (2021). The COVID-19 health equity twindemic: Statewide epidemiologic trends of SARS-CoV-2 outcomes among racial minorities and in rural America. medRxiv. https://doi.org/10.1101/2021.03.03.21252861https://hdl.handle.net/1805/25723Background Early studies on COVID-19 identified unequal patterns in hospitalization and mortality in urban environments for racial and ethnic minorities. These studies were primarily single center observational studies conducted within the first few weeks or months of the pandemic. We sought to examine trends in COVID-19 morbidity and mortality over time for minority and rural populations, especially during the U.S. fall surge. Methods Statewide cohort of all adult residents in Indiana tested for SARS-CoV-2 infection between March 1 and December 31, 2020, linked to electronic health records. Primary measures were per capita rates of infection, hospitalization, and death. Age adjusted rates were calculated for multiple time periods corresponding to public health mitigation efforts. Results Morbidity and mortality increased over time with notable differences among sub-populations. Initially, per capita hospitalizations among racial minorities were 3-4 times higher than whites, and per capita deaths among urban residents were twice those of rural residents. By fall 2020, per capita hospitalizations and deaths in rural areas surpassed those of urban areas, and gaps between black/brown and white populations narrowed. Cumulative morbidity and mortality were highest among minority groups and in rural communities. Conclusions Burden of COVID-19 morbidity and mortality shifted over time, creating a twindemic involving disparities in outcomes based on race and geography. Health officials should explicitly measure disparities and adjust mitigation and vaccination strategies to protect vulnerable sub-populations with greater disease burden.enAttribution-NoDerivatives 4.0 InternationalCOVID-19epidemiologic trendsracial minoritiesrural populationsPreprint