Lin, GengjieJian, YajunOuyang, HaoLi, Lei2016-02-252016-02-252014-10-03Lin, G., Jian, Y., Ouyang, H., & Li, L. (2014). An Unexpected Deamination Reaction after Hydrolysis of the Pyrimidine (6-4) Pyrimidone Photoproduct. Organic Letters, 16(19), 5076–5079. http://doi.org/10.1021/ol502433h1523-7060https://hdl.handle.net/1805/8493Pyrimidine (6-4) pyrimidone photoproduct (6-4PP), a common DNA photolesion formed under solar irradiation, was indicated to hydrolyze under strong basic conditions, breaking the N3–C4 bond at the 5′-thymine. The reanalysis of this reaction revealed that the resulting water adduct may not be stable as previously proposed; it readily undergoes an esterification reaction induced by the 5-OH group at 6-4PP to form a five-membered ring, eliminating a molecule of ammonia.en-USIUPUI Open Access PolicyPyrimidineschemistryPyrimidinonesArticle