Montironi, RodolfoScarpelli, MarinaMazzucchelli, RobertaLopez-Beltran, AntonioSantoni, MatteoBriganti, AlbertoMontorsi, FrancescoCheng, Liang2015-10-302015-10-302014-10-18Montironi, R., Scarpelli, M., Mazzucchelli, R., Lopez-Beltran, A., Santoni, M., Briganti, A., … Cheng, L. (2014). Does prostate acinar adenocarcinoma with Gleason Score 3 + 3 = 6 have the potential to metastasize? Diagnostic Pathology, 9, 190. http://doi.org/10.1186/s13000-014-0190-zhttps://hdl.handle.net/1805/7303Background: There is a worldwide debate involving clinicians, uropathologists as well as patients and their families on whether Gleason score 6 adenocarcinoma should be labelled as cancer. Case description: We report a case of man diagnosed with biopsy Gleason score 6 acinar adenocarcinoma and classified as low risk (based on a PSA of 5 ng/mL and stage cT2a) whose radical prostatectomy specimen initially showed organ confined Gleason score 3 + 3 = 6, WHO nuclear grade 3, acinar adenocarcinoma with lymphovascular invasion and secondary deposit in a periprostatic lymph node. When deeper sections were cut to the point that almost all the slice present in the paraffin block was sectioned, a small tumor area (<5% of the whole tumor) of Gleason pattern 4 (poorly formed glands) was found in an extraprostatic position. Conclusion: The epilogue was that the additional finding changed the final Gleason score to 3 + 3 = 6 with tertiary pattern 4 and the stage to pT3a. Virtual Slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/ vs/13000_2014_190en-USAttribution 3.0 United StatesProstate cancerGleason score 6 adenocarcinomaGleason scoreLymphovascular invasionLymph node metastasisPeriprostatic lymph nodeArticle