Gasparetto, CristinaJagannath, SundarRifkin, Robert M.Durie, Brian G. M.Narang, MohitTerebelo, Howard R.Toomey, KathleenHardin, James W.Wagner, LynneAilawadhi, SikanderOmel, James L.Srinivasan, ShankarDhalla, MazaherCatamero, DonnaKitali, AmaniAgarwal, AmitAbonour, RafatConnect MM Registry Investigators2024-05-022024-05-022022Gasparetto C, Jagannath S, Rifkin RM, et al. Effect of t (11;14) Abnormality on Outcomes of Patients With Newly Diagnosed Multiple Myeloma in the Connect MM Registry. Clin Lymphoma Myeloma Leuk. 2022;22(3):149-157. doi:10.1016/j.clml.2021.08.007https://hdl.handle.net/1805/40418Background: The t (11;14) (q13;32) translocation [t (11;14)] is present in ∼20% of patients with newly diagnosed multiple myeloma (NDMM), but studies examining its prognostic ability have yielded divergent results, and data are lacking on outcomes from first-line therapy. Patients and methods: Data from the Connect MM Registry, a large US, multicenter, prospective observational cohort study of patients with NDMM were used to examine the effect of t (11;14) status on first-line therapy outcomes in the Overall population (n = 1574) and race groups (African American [AA] vs. non-African American [NAA]). Results: Baseline characteristics were generally similar between patients with (n = 378) and without (n = 1196) t (11;14). Prevalence of t (11;14) was similar by race (AA, 27%; NAA, 24%). In the overall population, regardless of first-line therapy, t (11;14) status did not affect progression-free survival (hazard ratio, 1.02; P = 0.7675) or overall survival (hazard ratio, 0.99; P = .9417). AA patients with t (11;14) had higher likelihood of death (Nominal Cox regression P = .0298) vs. patients without t (11;14). Conclusions: Acknowledging observational study and inferential limitations, this exploratory analysis of a predominantly community-based population suggests that t (11;14) is a neutral prognostic factor in the general MM population but may be a negative factor for overall survival in AA patients.en-USAttribution 4.0 InternationalCommunitySurvivalTranslocationAfrican AmericanReal-worldArticle