Roper, Randall J.Hawley, LauraGoodlett, Charles R.2022-05-052022-05-052020Roper RJ, Hawley L, Goodlett CR. Influence of allelic differences in Down syndrome. Prog Brain Res. 2020;251:29-54. doi:10.1016/bs.pbr.2019.09.001https://hdl.handle.net/1805/28855Both trisomic and non-trisomic genes may affect the incidence and severity of phenotypes associated with Down syndrome (DS). The importance of extra (trisomic) genetic material is emphasized in DS, with less emphasis to the allelic composition of candidate trisomic genes in defining the trisomic gene-phenotype relationship in DS. Allelic differences in non-trisomic genes have been shown to be important moderators of cardiac, leukemia, and developmental phenotypes associated with DS. Trisomic mouse models provide an in vivo genetic platform for examining the gene-phenotype relationship, including the influence of allelic variants, on DS-like phenotypes. DS mouse models have differing trisomic genetic makeup, and optimal development, viability and translational value of these mouse models may require a non-inbred genetic background with heterogeneity at many loci. Additionally, understanding the contribution of specific genes or regions to DS phenotypes often requires the utilization of genetically manipulated mice that may be established on a different inbred background than the trisomic mice. The impact of allelic differences of trisomic and background genes in human and model systems may offer insight into the variability in occurrence and severity of trisomic phenotypes.en-USPublisher PolicyAllelic variationDown syndromeMouse modelsPhenotypic variabilityTrisomy 21Article