Bailey, MichaelCunitz, BryanDunmire, BarbrinaPaun, MarlaLee, FranklinRoss, SusanLingeman, JamesCoburn, MichaelWessells, HunterSorensen, MathewHarper, Jonathan2016-04-112016-04-112014-09-03Bailey, M., Cunitz, B., Dunmire, B., Paun, M., Lee, F., Ross, S., … Harper, J. (2014). Ultrasonic propulsion of kidney stones: preliminary results of human feasibility study. IEEE International Ultrasonics Symposium : [proceedings]. IEEE International Ultrasonics Symposium, 2014, 511–514. http://doi.org/10.1109/ULTSYM.2014.0126https://hdl.handle.net/1805/9246One in 11 Americans has experienced kidney stones, with a 50% average recurrence rate within 5-10 years. Ultrasonic propulsion (UP) offers a potential method to expel small stones or residual fragments before they become a recurrent problem. Reported here are preliminary findings from the first investigational use of UP in humans. The device uses a Verasonics ultrasound engine and Philips HDI C5-2 probe to generate real-time B-mode imaging and targeted "push" pulses on demand. There are three arms of the study: de novo stones, post-lithotripsy fragments, and the preoperative setting. A pain questionnaire is completed prior to and following the study. Movement is classified based on extent. Patients are followed for 90 days. Ten subjects have been treated to date: three de novo, five post-lithotripsy, and two preoperative. None of the subjects reported pain associated with the treatment or a treatment related adverse event, beyond the normal discomfort of passing a stone. At least one stone was moved in all subjects. Three of five post-lithotripsy subjects passed a single or multiple stones within 1-2 weeks following treatment; one subject passed two (1-2 mm) fragments before leaving clinic. In the pre-operative studies we successfully moved 7 - 8 mm stones. In four subjects, UP revealed multiple stone fragments where the clinical image and initial ultrasound examination indicated a single large stone.en-USPublisher Policybiomedical ultrasonicsimage sequenceskidneymedical image processingultrasonic imagingultrasonic therapyAcousticsForceImagingLithotripsyProbesPropulsionConference proceedings