Qiu, BinBell, Richard L.Cao, YongZhang, LinglingStewart, Robert B.Graves, TamaraLumeng, LawrenceYong, WeidongLiang, Tiebing2016-12-082016-12-082016-07-20Qiu, B., Bell, R. L., Cao, Y., Zhang, L., Stewart, R. B., Graves, T., … Liang, T. (2016). Npy deletion in an alcohol non-preferring rat model elicits differential effects on alcohol consumption and body weight. Journal of Genetics and Genomics = Yi Chuan Xue Bao, 43(7), 421–430. https://doi.org/10.1016/j.jgg.2016.04.0101673-8527https://hdl.handle.net/1805/11583Neuropeptide Y (NPY) is widely expressed in the central nervous system and influences many physiological processes. It is located within the rat quantitative trait locus (QTL) for alcohol preference on chromosome 4. Alcohol-nonpreferring (NP) rats consume very little alcohol, but have significantly higher NPY expression in the brain than alcohol-preferring (P) rats. We capitalized on this phenotypic difference by creating an Npy knockout (KO) rat using the inbred NP background to evaluate NPY effects on alcohol consumption. Zinc finger nuclease (ZNF) technology was applied, resulting in aen-USPublisher PolicyAlcohol drinking behaviorBDNFCRH and receptorsKnockout ratMelanocortin and receptorsNPY and receptorsArticle