Kloske, Courtney M.Belloy, Michael E.Blue, Elizabeth E.Bowman, Gregory R.Carrillo, Maria C.Chen, XiaoyingChiba-Falek, OrnitDavis, Albert A.Di Paolo, GilbertGarretti, FrancescaGate, DavidGolden, Lesley R.Heinecke, Jay W.Herz, JoachimHuang, YadongIadecola, CostantinoJohnson, Lance A.Kanekiyo, TakahisaKarch, Celeste M.Khvorova, AnastasiaKoppes-den Hertog, Sascha J.Lamb, Bruce T.Lawler, Paige E.Le Guen, YannLitvinchuk, AlexandraLiu, Chia-ChenMahinrad, SiminMarcora, EdoardoMarino, ClaudiaMichaelson, Danny M.Miller, Justin J.Morganti, Josh M.Narayan, Priyanka S.Naslavsky, Michel S.Oosthoek, MarliesRamachandran, Kapil V.Ramakrishnan, AbhiramiRaulin, Ana-CarolineRobert, AikoSaleh, Rasha N. M.Sexton, ClaireShah, NilomiShue, FrancisSible, Isabel J.Soranno, AndreaStrickland, Michael R.Tcw, JuliaThierry, ManonTsai, Li-HueiTuckey, Ryan A.Ulrich, Jason D.van der Kant, RikWang, NaWellington, Cheryl L.Weninger, Stacie C.Yassine, Hussein N.Zhao, NaBu, GuojunGoate, Alison M.Holtzman, David M.2024-11-132024-11-132024Kloske CM, Belloy ME, Blue EE, et al. Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference. Alzheimers Dement. 2024;20(9):6590-6605. doi:10.1002/alz.13877https://hdl.handle.net/1805/44538Introduction: The apolipoprotein E gene (APOE) is an established central player in the pathogenesis of Alzheimer's disease (AD), with distinct apoE isoforms exerting diverse effects. apoE influences not only amyloid-beta and tau pathologies but also lipid and energy metabolism, neuroinflammation, cerebral vascular health, and sex-dependent disease manifestations. Furthermore, ancestral background may significantly impact the link between APOE and AD, underscoring the need for more inclusive research. Methods: In 2023, the Alzheimer's Association convened multidisciplinary researchers at the "AAIC Advancements: APOE" conference to discuss various topics, including apoE isoforms and their roles in AD pathogenesis, progress in apoE-targeted therapeutic strategies, updates on disease models and interventions that modulate apoE expression and function. Results: This manuscript presents highlights from the conference and provides an overview of opportunities for further research in the field. Discussion: Understanding apoE's multifaceted roles in AD pathogenesis will help develop targeted interventions for AD and advance the field of AD precision medicine. Highlights: APOE is a central player in the pathogenesis of Alzheimer's disease. APOE exerts a numerous effects throughout the brain on amyloid-beta, tau, and other pathways. The AAIC Advancements: APOE conference encouraged discussions and collaborations on understanding the role of APOE.en-USAttribution 4.0 InternationalAPOEAlzheimer's diseaseApolipoprotein EConference proceedingsDementiaLipidsMicrogliaNeuroinflammationRisk factorTherapeuticsVasculatureArticle