He, RongjunZeng, Li-FanHe, YantaoWu, LiGunawan, Andrea MichelleZhang, Zhong-Yin2025-05-272025-05-272013He R, Zeng LF, He Y, Wu L, Gunawan AM, Zhang ZY. Organocatalytic multicomponent reaction for the acquisition of a selective inhibitor of mPTPB, a virulence factor of tuberculosis. Chem Commun (Camb). 2013;49(20):2064-2066. doi:10.1039/c3cc38961hhttps://hdl.handle.net/1805/48369Mycobacterium protein tyrosine phosphatase B (mPTPB) is essential for the survival and persistence of Mycobacterium in the host. Thus small molecule inhibitors of mPTPB are potential anti-TB agents. We developed an efficient organocatalytic multicomponent reaction (MCR) between pyrrole, formaldehyde and aniline, affording a potent and selective mPTPB inhibitor with an IC(50) value of 1.5 μM and >50-fold specificity. Our studies provide a successful example of using organocatalysis as a discovery tool for the acquisition of PTP inhibitors.en-USPublisher PolicyAntitubercular agentsBacterial proteinsEnzyme inhibitorsMycobacterium tuberculosisVirulence factorsArticle